Peptide Database

Peptide NameSLAY-screened peptide P4992

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length17 amino acids

Chemical FormulaC85H131N19O23S

DescriptionStandard

        FDNLGACPVLWGLTLLS
    

Molecular Weight1819.13 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-1.25

Net Charge (pH 7.4) -1.47

Charge Density (pH 7.0) -0.0735

GRAVY Index1.09

Hydrophobic Moment 0.18

Boman Index0.50

Instability Index68.01

Aliphatic Index 137.65

Aromaticity 0.1176

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 656.77

LogP -3.55

H-bond Donors 23.0

H-bond Acceptors 23.0

Rotatable Bonds 54.0

Heavy Atoms 128.0

Ring Count 4.0

Amide Bonds 17.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0173990 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/