Peptide Database

Peptide NameDermatoxin-S1 (DRT-S1) (Dermatoxin)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length77 amino acids

Chemical FormulaC369H597N97O117S3

DescriptionStandard

        MAFLKKSLFLILFLGLVPLSFCENDKREGENEEEQDDDQSEEKRALGTLLKGVGSAVATVGKMVADQFGKLLQAGQG
    

Molecular Weight8360.46 Da

Isoelectric Point (pI)4.68

Net Charge (pH 7.0)-4.49

Net Charge (pH 7.4) -4.75

Charge Density (pH 7.0) -0.0583

GRAVY Index-0.18

Hydrophobic Moment 0.66

Boman Index0.03

Instability Index45.24

Aliphatic Index 92.47

Aromaticity 0.0649

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3479.98

LogP -33.39

H-bond Donors 117.0

H-bond Acceptors 116.0

Rotatable Bonds 295.0

Heavy Atoms 586.0

Ring Count 6.0

Amide Bonds 83.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0115511 VERIFIED: YES

Provenance & Taxonomy

OrganismPhyllomedusa sauvagei [Animal]

FamilyDermatoxin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Mollicute Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetStaphylococcus aureus

RECORD: Rec_0185040 VERIFIED: YES

Provenance & Taxonomy

OrganismPhyllomedusa sauvagei [Animal]

FamilyDermatoxin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Mollicute Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetPseudomonas aeruginosa

RECORD: Rec_0199086 VERIFIED: YES

Provenance & Taxonomy

OrganismPhyllomedusa sauvagei [Animal]

FamilyDermatoxin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Mollicute Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetBurkholderia cepacia

RECORD: Rec_0275083 VERIFIED: YES

Provenance & Taxonomy

OrganismPhyllomedusa sauvagei [Animal]

FamilyDermatoxin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Mollicute Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetSalmonella Typhimurium

RECORD: Rec_0282163 VERIFIED: YES

Provenance & Taxonomy

OrganismPhyllomedusa sauvagei [Animal]

FamilyDermatoxin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Mollicute Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetBacillus megaterium

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