Peptide Database

Peptide NameSLAY-screened peptide P2884

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC111H169N21O28S

DescriptionStandard

        PLPLLYSPPYYSQIIPCSLL
    

Molecular Weight2277.72 Da

Isoelectric Point (pI)5.90

Net Charge (pH 7.0)-0.05

Net Charge (pH 7.4) -0.13

Charge Density (pH 7.0) -0.0027

GRAVY Index0.64

Hydrophobic Moment 0.23

Boman Index0.42

Instability Index61.32

Aliphatic Index 136.50

Aromaticity 0.1500

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4470.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 731.54

LogP -1.60

H-bond Donors 25.0

H-bond Acceptors 29.0

Rotatable Bonds 62.0

Heavy Atoms 161.0

Ring Count 8.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0394498 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/