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MYP_019795
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Basic Information
Brevibacillin I
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
not Standard
14 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XXLXIIVKIVKYLV
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0102344 VERIFIED: YES
Provenance & Taxonomy
Brevibacillus laterosporus DSM 28 [Bacterium]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
C6 fatty acyl (FA) chain (C6H1203), o: D-Ornithine, k: D-Lysine, y: D-Tyrosine at 1; non-canonical residue code at 2; ornithine at 4; C6 fatty acyl (FA) chain (C6H1203), o: D-Ornithine, k: D-Lysine, y: D-Tyrosine
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Enterococcus faecium LMG16003
2 μg/mL
MIC
PMID34220785 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34220785/
RECORD: Rec_0107578 VERIFIED: YES
Provenance & Taxonomy
Brevibacillus laterosporus DSM 28 [Bacterium]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
C6 fatty acyl (FA) chain (C6H1203), o: D-Ornithine, k: D-Lysine, y: D-Tyrosine at 1; non-canonical residue code at 2; ornithine at 4; C6 fatty acyl (FA) chain (C6H1203), o: D-Ornithine, k: D-Lysine, y: D-Tyrosine
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Enterococcus faecalis LMG16216
2 μg/mL
MIC
PMID34220785 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34220785/
RECORD: Rec_0111755 VERIFIED: YES
Provenance & Taxonomy
Brevibacillus laterosporus DSM 28 [Bacterium]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
C6 fatty acyl (FA) chain (C6H1203), o: D-Ornithine, k: D-Lysine, y: D-Tyrosine at 1; non-canonical residue code at 2; ornithine at 4; C6 fatty acyl (FA) chain (C6H1203), o: D-Ornithine, k: D-Lysine, y: D-Tyrosine
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa LMG6395
64 μg/mL
MIC
PMID34220785 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34220785/
RECORD: Rec_0216458 VERIFIED: YES
Provenance & Taxonomy
Brevibacillus laterosporus DSM 28 [Bacterium]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
C6 fatty acyl (FA) chain (C6H1203), o: D-Ornithine, k: D-Lysine, y: D-Tyrosine at 1; non-canonical residue code at 2; ornithine at 4; C6 fatty acyl (FA) chain (C6H1203), o: D-Ornithine, k: D-Lysine, y: D-Tyrosine
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Klebsiella pneumoniae LMG20218
64 μg/mL
MIC
PMID34220785 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34220785/
RECORD: Rec_0255391 VERIFIED: YES
Provenance & Taxonomy
Brevibacillus laterosporus DSM 28 [Bacterium]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
C6 fatty acyl (FA) chain (C6H1203), o: D-Ornithine, k: D-Lysine, y: D-Tyrosine at 1; non-canonical residue code at 2; ornithine at 4; C6 fatty acyl (FA) chain (C6H1203), o: D-Ornithine, k: D-Lysine, y: D-Tyrosine
Bio-Activity Profile
Hemolytic
human RBCs
18.8±0.5 μg/mL
HC50
PMID34220785 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34220785/
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