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MYP_019750
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Basic Information
sHR2-2
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Standard
60 amino acids
C298H479N79O102
Standard
Sequence
PKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYE
Physicochemical Analysis
6800.46 Da
4.57
-5.93
-6.07
-0.0988
-0.72
0.70
-0.11
30.70
100.67
0.0500
2980.00
2980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2975.37
-29.78
98.0
97.0
238.0
479.0
6.0
67.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0183385 VERIFIED: YES
Provenance & Taxonomy
Severe acute respiratory syndrome-related coronavirus [Virus]
Virus-derived peptide
694009;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Fusion inhibitor
SARS coronavirus (Fusion); Vero
24 μM
EC50
PaperSevere acute respiratory syndrome coronavirus (SARS-CoV) infection inhibition using spike protein heptad repeat-derived peptides. | Bosch BJ, Martina BE, Van Der Zee R, Lepault J, Haijema BJ, Versluis C, Heck AJ, De Groot R, Osterhaus AD, Rottier PJ. | Proc Natl Acad Sci U S A. 2004 | PMID:15150417 PMID15150417 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15150417/
RECORD: Rec_0272723 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 15150417 PMID15150417 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15150417/
RECORD: Rec_0285074 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
SARS-CoV: inhibition of SARS-CoV infection in Vero 118 cells
24±2.8 μM
EC50
PaperPubMed PMID: 15150417 PMID15150417 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15150417/
RECORD: Rec_0308005 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-SARS-CoV Fusion inhibition
SARS-CoV | 118 cells
24±2.8 μM
EC50
Mammalian: >20 h; Yeast: >20 h; E. coli: ?
PaperSevere acute respiratory syndrome coronavirus (SARS-CoV) infection inhibition using spike protein heptad repeat-derived peptides. | Bosch BJ, Martina BE, Van Der Zee R, Lepault J, Haijema BJ, Versluis C, Heck AJ, De Groot R, Osterhaus AD, Rottier PJ. | Proc Natl Acad Sci U S A. 2004 Jun 1;101(22):8455-60. | DOI:10.1073/pnas.0400576101 | PMID:15150417 PMID15150417 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15150417/
RECORD: Rec_0310268 VERIFIED: YES
Provenance & Taxonomy
Severe acute respiratory syndrome-related coronavirus [Virus]
HR2-derived fusion inhibitor
694009
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Severe acute respiratory syndrome coronavirus
24 μM
EC50
PaperSevere acute respiratory syndrome coronavirus (SARS-CoV) infection inhibition using spike protein heptad repeat-derived peptides PMID15150417 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15150417/
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