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MYP_019698
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Basic Information
Alpha-defensin PhD-4
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive ▸ Anti-Staphylococcus aureus
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
30 amino acids
C156H225N43O37S6
Standard
Sequence
ACYCRIPACFAGERRYGTCFYLGRVWAFCC
Physicochemical Analysis
3487.11 Da
8.68
2.74
2.45
0.0912
0.44
0.35
0.12
58.68
49.00
0.2333
9970.00
10345.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1280.04
-9.14
54.0
46.0
103.0
242.0
9.0
29.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0375696 VERIFIED: YES
Provenance & Taxonomy
Papio hamadryas [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
2-30, 4-19, 9-29
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Escherichia coli ML35p
7.1 μM
MIC
PMID20155756 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20155756/
RECORD: Rec_0396626 VERIFIED: NO
Provenance & Taxonomy
Hamadryas baboon [Animal]; Mammalia [Animal]
33208; 40674
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Paclitaxel conjugation
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0397135 VERIFIED: YES
Provenance & Taxonomy
Papio hamadryas [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
2-30, 4-19, 9-29
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Candida albicans 820
50 μM
MIC
PMID20155756 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20155756/
RECORD: Rec_0408306 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Papio hamadryas [Synthetic]
Defensin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
the Gram- bacterium Escherichia coli ML35p
2.4 μM
MIC
PaperDe novo sequencing of two new cyclic theta-defensins from baboon (Papio hamadryas) leukocytes by matrix-assisted laser desorption/ionization mass spectrometry
RECORD: Rec_0419269 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Papio hamadryas [Synthetic]
Defensin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Listeria monocytogenes EGD
2.2 μM
MIC
PaperDe novo sequencing of two new cyclic theta-defensins from baboon (Papio hamadryas) leukocytes by matrix-assisted laser desorption/ionization mass spectrometry
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