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MYP_019698
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Basic Information
Alpha-defensin PhD-4
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive ▸ Anti-Staphylococcus aureus
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
30 amino acids
C156H225N43O37S6
Standard
Sequence
ACYCRIPACFAGERRYGTCFYLGRVWAFCC
Physicochemical Analysis
3487.11 Da
8.68
2.74
2.45
0.0912
0.44
0.35
0.12
58.68
49.00
0.2333
9970.00
10345.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1280.04
-9.14
54.0
46.0
103.0
242.0
9.0
29.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0311585 VERIFIED: YES
Provenance & Taxonomy
Papio hamadryas [Animal]
Alpha-defensin; Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
disulfide bond; sites not specified
Bio-Activity Profile
Antimicrobial Defensin Antifungal Anti-MRSA Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic
Staphylococcus aureus
PMID20155756 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20155756/
RECORD: Rec_0322702 VERIFIED: YES
Provenance & Taxonomy
Papio hamadryas [Animal]
Alpha-defensin; Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
disulfide bond; sites not specified
Bio-Activity Profile
Antimicrobial Defensin Antifungal Anti-MRSA Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic
Candida albicans
PMID20155756 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20155756/
RECORD: Rec_0323145 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Papio hamadryas [Synthetic]
Defensin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
methicillin-resistant Staphylococcus aureus MRSA ATCC 33591
3.5 μM
MIC
PaperDe novo sequencing of two new cyclic theta-defensins from baboon (Papio hamadryas) leukocytes by matrix-assisted laser desorption/ionization mass spectrometry
RECORD: Rec_0361074 VERIFIED: YES
Provenance & Taxonomy
Papio hamadryas [Animal]
Defensin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID20155756 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20155756/
RECORD: Rec_0364845 VERIFIED: YES
Provenance & Taxonomy
Papio hamadryas [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
2-30, 4-19, 9-29
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Staphylococcus aureus ATCC 33591
3.5 μM
MIC
PMID20155756 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20155756/
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