Peptide Database

Peptide NameAlpha-defensin PhD-4

Function Ontology

Anticancer

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive ▸ Anti-Staphylococcus aureus

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length30 amino acids

Chemical FormulaC156H225N43O37S6

DescriptionStandard

        ACYCRIPACFAGERRYGTCFYLGRVWAFCC
    

Molecular Weight3487.11 Da

Isoelectric Point (pI)8.68

Net Charge (pH 7.0)2.74

Net Charge (pH 7.4) 2.45

Charge Density (pH 7.0) 0.0912

GRAVY Index0.44

Hydrophobic Moment 0.35

Boman Index0.12

Instability Index58.68

Aliphatic Index 49.00

Aromaticity 0.2333

Extinction Coeff. Reduced 9970.00

Extinction Coeff. Oxidized 10345.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1280.04

LogP -9.14

H-bond Donors 54.0

H-bond Acceptors 46.0

Rotatable Bonds 103.0

Heavy Atoms 242.0

Ring Count 9.0

Amide Bonds 29.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0126366 VERIFIED: YES

Provenance & Taxonomy

OrganismPapio hamadryas [Animal]

FamilyDefensin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermCyclization

Disulfide2-30, 4-19, 9-29

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

RECORD: Rec_0155377 VERIFIED: YES

Provenance & Taxonomy

OrganismPapio hamadryas [Animal]

FamilyDefensin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermCyclization

Disulfide2-30, 4-19, 9-29

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetEscherichia coli ML35p

Activity2.4 μM

MethodMIC

RECORD: Rec_0160299 VERIFIED: NO

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

-

RECORD: Rec_0170922 VERIFIED: YES

Provenance & Taxonomy

OrganismPapio hamadryas [Animal]

FamilyDefensin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermCyclization

Disulfide2-30, 4-19, 9-29

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetListeria monocytogenes EGD

Activity1.8 μM

MethodMIC

RECORD: Rec_0183873 VERIFIED: YES

Provenance & Taxonomy

OrganismPapio hamadryas [Animal]

FamilyAlpha-defensin; Defensin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidedisulfide bond; sites not specified

Bio-Activity Profile

Function

Antimicrobial Defensin Antifungal Anti-MRSA Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetEscherichia coli

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