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MYP_019698
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Basic Information
Alpha-defensin PhD-4
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive ▸ Anti-Staphylococcus aureus
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
30 amino acids
C156H225N43O37S6
Standard
Sequence
ACYCRIPACFAGERRYGTCFYLGRVWAFCC
Physicochemical Analysis
3487.11 Da
8.68
2.74
2.45
0.0912
0.44
0.35
0.12
58.68
49.00
0.2333
9970.00
10345.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1280.04
-9.14
54.0
46.0
103.0
242.0
9.0
29.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0002560 VERIFIED: YES
Provenance & Taxonomy
Papio hamadryas [Animal]
Alpha-defensin; Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
disulfide bond; sites not specified
Bio-Activity Profile
Antimicrobial Defensin Antifungal Anti-MRSA Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic
Listeria monocytogenes
PMID20155756 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20155756/
RECORD: Rec_0010767 VERIFIED: YES
Provenance & Taxonomy
Papio hamadryas [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
2-30, 4-19, 9-29
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Staphylococcus aureus ATCC 33591
50 μM
MIC
PMID20155756 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20155756/
RECORD: Rec_0018879 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperAntiCP 2.0: an updated model for predicting anticancer peptides (benchmark provenance; exact sequence-level experiment paper unresolved here) | https://pubmed.ncbi.nlm.nih.gov/32770192/
RECORD: Rec_0112040 VERIFIED: YES
Provenance & Taxonomy
Papio hamadryas [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
2-30, 4-19, 9-29
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Listeria monocytogenes EGD
2.2 μM
MIC
PMID20155756 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20155756/
RECORD: Rec_0115120 VERIFIED: YES
Provenance & Taxonomy
Papio hamadryas [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
2-30, 4-19, 9-29
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Candida albicans 820
3.9 μM
MIC
PMID20155756 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20155756/
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