Peptide Database

Peptide NamePituitary adenylate cyclase-activating peptide PACAP-38

Function Ontology

Enzyme Activator

Standard StatusStandard

Sequence Length38 amino acids

Chemical FormulaC204H332N64O54S

DescriptionStandard

        HSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYRQKIRNK
    

Molecular Weight4577.28 Da

Isoelectric Point (pI)10.56

Net Charge (pH 7.0)8.84

Net Charge (pH 7.4) 8.57

Charge Density (pH 7.0) 0.2326

GRAVY Index-1.07

Hydrophobic Moment 0.64

Boman Index-0.37

Instability Index32.14

Aliphatic Index 64.21

Aromaticity 0.1316

Extinction Coeff. Reduced 5960.00

Extinction Coeff. Oxidized 5960.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2000.03

LogP -19.29

H-bond Donors 74.0

H-bond Acceptors 65.0

Rotatable Bonds 160.0

Heavy Atoms 323.0

Ring Count 6.0

Amide Bonds 40.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0046229 VERIFIED: YES

Provenance & Taxonomy

OrganismParalichthys olivaceus [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

PAC1 receptor agonist cAMP signaling activator Enzyme Activator

TargetPAC1 receptor (PAC1R); HINAE cells

MethodIntracellular cAMP production assay in PAC1R-overexpressing HINAE cells