Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length187 amino acids

Chemical FormulaC927H1437N237O266S6

DescriptionStandard

        MLPSVMVVFAILSCTRGENPAVQVTLTDKWLQYVKHVGAGWIQDKLEHITFPDISGDVDILIGHVYYTLSGIRITKCDLPEPVLEFFQSTGLKTSIVGLNAALVGNWRTSFGIIHDSGSFDMAIFSVSLTSVVQLGRDPDGHLSITSIGCEPQVGNVAIQFHGGASFIFQPFVDHYKGKIVSVIQSN
    

Molecular Weight20350.14 Da

Isoelectric Point (pI)5.71

Net Charge (pH 7.0)-4.90

Net Charge (pH 7.4) -5.55

Charge Density (pH 7.0) -0.0262

GRAVY Index0.31

Hydrophobic Moment 0.58

Boman Index0.24

Instability Index30.17

Aliphatic Index 104.12

Aromaticity 0.0963

Extinction Coeff. Reduced 22460.00

Extinction Coeff. Oxidized 22585.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7930.89

LogP -88.29

H-bond Donors 274.0

H-bond Acceptors 274.0

Rotatable Bonds 659.0

Heavy Atoms 1436.0

Ring Count 36.0

Amide Bonds 200.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0281900 VERIFIED: NO

Provenance & Taxonomy

OrganismNothobranchius kuhntae [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria