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MYP_019631
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Basic Information
C16- N23
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Standard
23 amino acids
C113H193N39O35
Standard
Sequence
RQLLSGIVQQQNNLLRAIEAQQH
Physicochemical Analysis
2657.98 Da
9.61
0.85
0.60
0.0370
-0.56
0.57
-0.14
63.16
123.04
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1258.25
-14.64
41.0
37.0
94.0
187.0
1.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0075069 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
C16(hexadecanoic acid)
None
C16(hexadecanoic acid)
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1 | against cell; -cell; HXBc2 cells
1.931±0.187 μM
IC50
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperVirus-cell and cell-cell fusion mediated by the HIV-1 envelope glycoprotein is inhibited by short gp41 N-terminal membrane-anchored peptides lacking the critical pocket domain. | Wexler-Cohen Y, Ashkenazi A, Viard M, Blumenthal R, Shai Y. | FASEB J. 2010 Nov;24(11):4196-202. | DOI:10.1096/fj.09-151704 | PMID:20605950 PMID20605950 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20605950/
RECORD: Rec_0177766 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1
PMID20605950 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20605950/
RECORD: Rec_0216815 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
C16(hexadecanoic acid)
None
Bio-Activity Profile
Antimicrobial Antiviral
PMID20605950 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20605950/
RECORD: Rec_0257971 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
C16(hexadecanoic acid)
None
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1:inhibition of peptide against cell-cell fusion between Jurkat E6-1 and HXBc2 cells
1.931±0.187 μM
IC50
PMID20605950 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20605950/