Peptide Database

Peptide NameCyclotide vhl1

Function Ontology

Anticancer

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV

Standard StatusStandard

Sequence Length31 amino acids

Chemical FormulaC140H223N35O45S7

DescriptionStandard

        CGESCAMISFCFTEVIGCSCKNKVCYLNSIS
    

Molecular Weight3340.93 Da

Isoelectric Point (pI)6.10

Net Charge (pH 7.0)-0.30

Net Charge (pH 7.4) -0.59

Charge Density (pH 7.0) -0.0096

GRAVY Index0.69

Hydrophobic Moment 0.40

Boman Index0.22

Instability Index45.60

Aliphatic Index 72.26

Aromaticity 0.0968

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1865.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1290.75

LogP -15.43

H-bond Donors 51.0

H-bond Acceptors 52.0

Rotatable Bonds 110.0

Heavy Atoms 227.0

Ring Count 3.0

Amide Bonds 32.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0321133 VERIFIED: YES

Provenance & Taxonomy

OrganismViola hederacea [Plant]

FamilyCyclotide

Structure & Mods

ConfigBackbone-cyclized cyclotide scaffold with cystine-knot family annotation [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral

TargetHIV

Activity0.87 μM

MethodEC50

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