Peptide Database

Peptide Namegrowth/differentiation factor-7

Function Ontology

Neurological / Signaling ▸ Receptor modulation ▸ Agonist

Neurological / Signaling ▸ Signaling peptide

Standard StatusStandard

Sequence Length129 amino acids

Chemical FormulaC608H953N181O183S9

DescriptionStandard

        TALAGTRTAQGSGGGAGRGHGRRGRSRCSRKPLHVDFKELGWDDWIIAPLDYEAYHCEGLCDFPLRSHLEPTNHAIIQTLLNSMAPDAAPASCCVPARLSPISILYIDAANNVVYKQYEDMVVEACGCR
    

Molecular Weight14014.76 Da

Isoelectric Point (pI)6.46

Net Charge (pH 7.0)-1.22

Net Charge (pH 7.4) -1.79

Charge Density (pH 7.0) -0.0094

GRAVY Index-0.23

Hydrophobic Moment 0.56

Boman Index0.01

Instability Index45.84

Aliphatic Index 79.53

Aromaticity 0.0698

Extinction Coeff. Reduced 18450.00

Extinction Coeff. Oxidized 18825.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 5777.81

LogP -62.19

H-bond Donors 208.0

H-bond Acceptors 196.0

Rotatable Bonds 448.0

Heavy Atoms 981.0

Ring Count 24.0

Amide Bonds 135.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0186155 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyGtoPdb endogenous peptide ligand

Tax ID9606

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidereported in GtoPdb PTM annotation

Other ModsThe active peptide is a homodimer linked by a disulphide bond between cysteine residues at position 93 of each chain. Predicted disulphide bond formation between cysteine residues at positions 28 and 94, 57 and 126, and 61 and 128

Bio-Activity Profile

Function

Receptor agonist Signaling peptide

TargetGrowth/differentiation factor receptors (Human)