Peptide Database

Peptide NameSLAY-screened peptide P949

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC117H174N32O26S

DescriptionStandard

        PICHYPYPALQPLHRPYRAAL
    

Molecular Weight2476.90 Da

Isoelectric Point (pI)9.26

Net Charge (pH 7.0)2.12

Net Charge (pH 7.4) 1.94

Charge Density (pH 7.0) 0.1010

GRAVY Index-0.33

Hydrophobic Moment 0.68

Boman Index0.07

Instability Index92.71

Aliphatic Index 88.57

Aromaticity 0.1429

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4470.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 881.11

LogP -3.71

H-bond Donors 31.0

H-bond Acceptors 31.0

Rotatable Bonds 67.0

Heavy Atoms 176.0

Ring Count 10.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0183370 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/