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MYP_019373
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Basic Information
Signiferin-2.1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Enzyme modulation ▸ Enzyme inhibition ▸ nNOS inhibitor
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
15 amino acids
C72H128N18O17S
Standard
Sequence
IIGHLIKTALGMLGL
Physicochemical Analysis
1549.96 Da
8.76
0.85
0.59
0.0564
1.56
0.44
0.61
3.67
188.67
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
545.65
-1.35
19.0
20.0
53.0
108.0
1.0
14.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0111252 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0116915 VERIFIED: YES
Provenance & Taxonomy
Crinia signifera [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative Anti-Gram-positive Non-hemolytic
Bacillus cereus
PMID15317042;16470724;18601958 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15317042/
RECORD: Rec_0118323 VERIFIED: YES
Provenance & Taxonomy
Crinia signifera [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative Anti-Gram-positive Non-hemolytic
Enterococcus faecalis
PMID15317042;16470724;18601958 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15317042/
RECORD: Rec_0152603 VERIFIED: YES
Provenance & Taxonomy
Crinia signifera [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus ATCC 29213
12 μM
MIC
PMID15317042;16470724;18601958 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15317042/
RECORD: Rec_0160387 VERIFIED: YES
Provenance & Taxonomy
Crinia signifera [Animal]
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
12 μM
MIC
PMID18601958;16470724 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18601958/
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