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MYP_019373
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Basic Information
Signiferin-2.1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Enzyme modulation ▸ Enzyme inhibition ▸ nNOS inhibitor
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
15 amino acids
C72H128N18O17S
Standard
Sequence
IIGHLIKTALGMLGL
Physicochemical Analysis
1549.96 Da
8.76
0.85
0.59
0.0564
1.56
0.44
0.61
3.67
188.67
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
545.65
-1.35
19.0
20.0
53.0
108.0
1.0
14.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0014893 VERIFIED: YES
Provenance & Taxonomy
Crinia signifera [Animal]
Signiferin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
nNOS inhibitor
PaperR.J. Jackway et al. / Regulatory Peptides 151 (2008) 80-87. Disulfide-containing peptides from the glandular skin secretions of froglets of the genus Crinia: Structure, activity and evolutionary trends Evidence URLhttps://www.uniprot.org/uniprotkb/P86131/entry
RECORD: Rec_0015691 VERIFIED: YES
Provenance & Taxonomy
Crinia signifera [Animal]
Signiferin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
12.0 μM
MIC
PaperR.J. Jackway et al. / Regulatory Peptides 151 (2008) 80-87. Disulfide-containing peptides from the glandular skin secretions of froglets of the genus Crinia: Structure, activity and evolutionary trends Evidence URLhttps://www.uniprot.org/uniprotkb/P86131/entry
RECORD: Rec_0020432 VERIFIED: YES
Provenance & Taxonomy
Crinia signifera [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative Anti-Gram-positive Non-hemolytic
Staphylococcus epidermidis
PMID15317042;16470724;18601958 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15317042/
RECORD: Rec_0021656 VERIFIED: YES
Provenance & Taxonomy
Crinia signifera [Animal]
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Listeria innocua
50 μM
MIC
PMID18601958;16470724 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18601958/
RECORD: Rec_0022209 VERIFIED: YES
Provenance & Taxonomy
Crinia signiferin [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Escherichia coli ATCC 35218
>100 μM
IC50
PaperHost-defence skin peptides of the Australian Streambank Froglet Crinia riparia: isolation and sequence determination by positive and negative ion electrospray mass spectrometry.
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