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MYP_019347
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Basic Information
Paenibacterin
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
13 amino acids
C66H123N17O17
Standard
Sequence
KVTKSVKSIPVKI
Physicochemical Analysis
1426.79 Da
10.48
3.76
3.55
0.2889
0.16
0.48
-0.02
-2.19
126.92
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
568.50
-4.34
20.0
21.0
50.0
100.0
1.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0003078 VERIFIED: YES
Provenance & Taxonomy
Paenibacillus thiaminolyticus [Bacterium]
Bacteriocin
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Lipidation
Esterification
H7, and S. enterica serovar Typhimurium. MOA: The peptide binds to LPS (BBL) and can disrupt bacterial membranes (Huang and Yousef, 2014)
Bio-Activity Profile
Antimicrobial
Gram-positive
PaperIsolation of a Paenibacillus sp. strain and structural elucidation of its broad-spectrum lipopeptide antibiotic.
RECORD: Rec_0084755 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0152769 VERIFIED: YES
Provenance & Taxonomy
Paenibacillus thiaminolyticus [Bacterium]
Bacteriocin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Broad-spectrum
PaperPubMed PMID: 22367082 PMID22367082 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22367082/
RECORD: Rec_0210099 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0263353 VERIFIED: YES
Provenance & Taxonomy
Paenibacillus polymyxa [Bacterium]; Bacteria [Bacterium]
1405; 2
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID24583094 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24583094/