Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length554 amino acids

Chemical FormulaC2695H4245N777O745S26

DescriptionStandard

        MGDVPVQPAHPPQDGHWRHRSLLPAATHMGSGPTMGPAAAVGHAPGSCRCPGADGSLPARVHLLSGATRGMWLCLLLLMAACVPTTTSSPGIKGRVTRSALEYGQRFGLELLRSLLQKEHNVNLQGSYQAPLLGRLNYTVPQIHIHELQMNDSTVDFAEDVGVQLTVHRARIQLNATWQAQLGAWQDSGSLRLRIRDLAVAVLLGLGADEHGHPSVWDAGCDARGTDLRLEFRRGQSWLYNLLVPLLQRTLRQQLNKQGEFFGVHGRWQNPFSAQPVGLPELQEPMLLVAITEFVANTAAFVYFTAGALRRNITAEMLPRRFPLKLNTESMGSFAPQLQQHFPSCPMELHLWARRQPLLSCHPNALHGALFGSAEAFVVLPNATRVPAFLLNIDANVTAKPTIAGNRLGGTVGLQSLSVVQVMSHVGPLQVQKLENMLKFGLWLFGVPWANKRLRPGVPLPTPHGITLLHPHLSLHEVSAIPVPSPPSLCLHALLLPLSPCRASCSSPQTCATSPETCNGVGRCWPYELSCIPLPLASSQPRLSSGSHYPLSWD
    

Molecular Weight60283.98 Da

Isoelectric Point (pI)9.06

Net Charge (pH 7.0)11.51

Net Charge (pH 7.4) 9.81

Charge Density (pH 7.0) 0.0208

GRAVY Index-0.03

Hydrophobic Moment 0.72

Boman Index0.10

Instability Index58.90

Aliphatic Index 93.86

Aromaticity 0.0650

Extinction Coeff. Reduced 76430.00

Extinction Coeff. Oxidized 77305.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0122561 VERIFIED: YES

Provenance & Taxonomy

OrganismGallus gallus [Animal]

FamilyBPI/LBP

Tax ID9031

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria