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MYP_019204
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Basic Information
[R10K]MVIIA (omega-conotoxin MVIIA analogue)
Miscellaneous
Standard
25 amino acids
C102H177N33O33S7
Standard
Sequence
CKGKGAKCSKLMYDCCTGSCRSGKC
Physicochemical Analysis
2618.15 Da
9.10
4.70
4.40
0.1878
-0.44
0.42
-0.21
48.43
19.60
0.0400
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1092.17
-16.35
46.0
45.0
92.0
175.0
1.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0041280 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Structure & Mods
linear peptide; DSSP H 0.0%, E 24.0%, T 40.0%, C 36.0% [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Miscellaneous Toxin Ion channel blocker Calcium channel blocker N-type CaV2.2 inhibitor
rat brain N-type voltage-sensitive calcium channels (CaV2.2)
10.62±0.046
pIC50 (radioligand competition binding; [125I]GVIA displacement)
Paperω-Conotoxin CVID Inhibits a Pharmacologically Distinct Voltage-sensitive Calcium Channel Associated with Transmitter Release from Preganglionic Nerve Terminals PMID12441339; 22058133 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22058133/
RECORD: Rec_0432348 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Toxin Ion channel blocker Calcium channel blocker N-type CaV2.2 inhibitor
rat submandibular ganglion preganglionic cholinergic nerve terminals
47 %
% inhibition of evoked EPSP amplitude at 100 nM
Paperω-Conotoxin CVID Inhibits a Pharmacologically Distinct Voltage-sensitive Calcium Channel Associated with Transmitter Release from Preganglionic Nerve Terminals PMID12441339
RECORD: Rec_0432349 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Toxin Ion channel blocker Calcium channel blocker N-type CaV2.2 inhibitor
rat CaV2.2 peripheral α1B-b (α1B alone)
0.24±0.05 nM
Kd (two-electrode voltage-clamp kinetics in Xenopus oocytes)
Paper[R10K]MVIIA pharmacology on recombinant rat CaV2.2 channels and auxiliary subunits PMID15166237
RECORD: Rec_0432350 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Toxin Ion channel blocker Calcium channel blocker N-type CaV2.2 inhibitor
rat CaV2.2 peripheral α1B-b + β3
0.11±0.02 nM
Kd (two-electrode voltage-clamp kinetics in Xenopus oocytes)
Paper[R10K]MVIIA pharmacology on recombinant rat CaV2.2 channels and auxiliary subunits PMID15166237
RECORD: Rec_0432351 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Toxin Ion channel blocker Calcium channel blocker N-type CaV2.2 inhibitor
rat CaV2.2 peripheral α1B-b + β3 + α2δ
15.6±2.6 nM
Kd (two-electrode voltage-clamp kinetics in Xenopus oocytes)
Paper[R10K]MVIIA pharmacology on recombinant rat CaV2.2 channels and auxiliary subunits PMID15166237
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