Peptide Database

Peptide NameUnnamed

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-Retrovirus ▸ Anti-Lentivirus ▸ Anti-FIV

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor

Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC109H178N42O28S

DescriptionStandard

        RNKSNLHTEARFRIRCRWNV
    

Molecular Weight2556.91 Da

Isoelectric Point (pI)11.83

Net Charge (pH 7.0)4.84

Net Charge (pH 7.4) 4.57

Charge Density (pH 7.0) 0.2420

GRAVY Index-1.32

Hydrophobic Moment 0.38

Boman Index-0.57

Instability Index68.18

Aliphatic Index 58.50

Aromaticity 0.1000

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1203.24

LogP -13.45

H-bond Donors 46.0

H-bond Acceptors 35.0

Rotatable Bonds 86.0

Heavy Atoms 180.0

Ring Count 4.0

Amide Bonds 22.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0248126 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antiviral

RECORD: Rec_0295116 VERIFIED: YES

Provenance & Taxonomy

OrganismFeline immunodeficiency virus [Virus]

FamilyVirus-derived peptide

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral Fusion inhibitor

TargetFeline immunodeficiency virus (Syncytium formation); CrFK

Activity2 %

MethodSyncytia assay

PaperInhibition of feline immunodeficiency virus infection in vitro by envelope glycoprotein synthetic peptides. | Lombardi S, Massi C, Indino E, La Rosa C, Mazzetti P, Falcone ML, Rovero P, Fissi A, Pieroni O, Bandecchi P, Esposito F, Tozzini F, Bendinelli M, Garzelli C. | Virology. 1996 | PMID:8661378 PMID8661378 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8661378/

RECORD: Rec_0358843 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-FIV Replication inhibition

TargetFeline immunodeficiency virus (FIV) | fibroblastoid cells

Activity16 μg/mL

Method% inhibition

Half-LifeMammalian: 1 h; Yeast: 2 min; E. coli: 2 min

PaperInhibition of feline immunodeficiency virus infection in vitro by envelope glycoprotein synthetic peptides. | Lombardi S, Massi C, Indino E, La Rosa C, Mazzetti P, Falcone ML, Rovero P, Fissi A, Pieroni O, Bandecchi P, Esposito F, Tozzini F, Bendinelli M, Garzelli C. | Virology. 1996 Jun 15;220(2):274-84. | DOI:10.1006/viro.1996.0315 | PMID:8661378 PMID8661378 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8661378/