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MYP_019107
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Basic Information
Safencin (48-70)[G2,18W;E4K]
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
25 amino acids
C152H245N43O32
Standard
Sequence
AWKKTIRQYLKNEIKKKWRKAVIAW
Physicochemical Analysis
3186.84 Da
10.79
7.79
7.59
0.3116
-0.98
0.70
-0.29
15.20
86.00
0.1600
17990.00
17990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1278.97
-5.13
47.0
40.0
111.0
227.0
7.0
26.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0021010 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus
8 μM
PMID29463889 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29463889/
RECORD: Rec_0165269 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Bacteriocin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiparasitic
L. donovani
2.60 μM
IC50
PaperRationally Designed Minimal Bioactive Domains of AS-48 Bacteriocin Homologs Possess Potent Antileishmanial Properties PMID36342284 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/36342284/
RECORD: Rec_0192967 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Pseudomonas aeruginosa PAO1
8 μM
PMID29463889 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29463889/
RECORD: Rec_0195134 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Bacteriocin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiparasitic Toxicity
THP-1 cells
<20 μM
CC50
PaperRationally Designed Minimal Bioactive Domains of AS-48 Bacteriocin Homologs Possess Potent Antileishmanial Properties PMID36342284 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/36342284/
RECORD: Rec_0234586 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Xanthomonas axonopodis pv. phaseoli ATCC 9563
1 μM
MIC
PMID29463889 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29463889/
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