Peptide Database

Peptide NameCathelicidin-related peptide Pt_CRAMP1 (Cathelicidin-related antimicrobial peptide) (CRAMP) (Vipericidin)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity

Standard StatusStandard

Sequence Length184 amino acids

Chemical FormulaC956H1468N234O289S9

DescriptionStandard

        MEGFFWKTWLVVAAFAIGGTSSLPHKPLTYEEAVDLAVSTYNGKSGEESLYRLLEAVPPPKWDPLSESNQELNLTIKETVCLVAEERSLEECDFQDDGAVMGCTGYFFFGESPPVLVLTCEPLGEDEEQNQEEEEEEEKEEDEKDQPRRVKRFKKFFMKLKKSVKKRVMKFFKKPMVIGVTFPF
    

Molecular Weight21151.86 Da

Isoelectric Point (pI)4.73

Net Charge (pH 7.0)-12.39

Net Charge (pH 7.4) -12.80

Charge Density (pH 7.0) -0.0673

GRAVY Index-0.51

Hydrophobic Moment 0.79

Boman Index-0.04

Instability Index60.20

Aliphatic Index 68.26

Aromaticity 0.1141

Extinction Coeff. Reduced 22460.00

Extinction Coeff. Oxidized 22710.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 8394.85

LogP -85.41

H-bond Donors 285.0

H-bond Acceptors 287.0

Rotatable Bonds 701.0

Heavy Atoms 1488.0

Ring Count 37.0

Amide Bonds 192.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0003234 VERIFIED: YES

Provenance & Taxonomy

OrganismPseudonaja textilis [Animal]

FamilyCathelicidin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Anti-Gram-positive Cytolytic Hemolytic

TargetEscherichia coli

RECORD: Rec_0126410 VERIFIED: YES

Provenance & Taxonomy

OrganismPseudonaja textilis [Animal]

FamilyCathelicidin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Anti-Gram-positive Cytolytic Hemolytic

TargetEnterococcus faecalis

RECORD: Rec_0195461 VERIFIED: YES

Provenance & Taxonomy

OrganismPseudonaja textilis [Animal]

FamilyCathelicidin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Anti-Gram-positive Cytolytic Hemolytic

TargetPseudomonas aeruginosa

RECORD: Rec_0389111 VERIFIED: YES

Provenance & Taxonomy

OrganismPseudonaja textilis [Animal]

FamilyCathelicidin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Anti-Gram-positive Cytolytic Hemolytic

TargetStaphylococcus aureus