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MYP_019096
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Basic Information
Proenkephalin-A fragment 1
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Neurological / Signaling ▸ Pain modulation ▸ Pronociceptive activity
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Standard
43 amino acids
C181H290N56O84
Standard
Sequence
DADEGDTLANSSDLLKELLGTGDNRAKDSHQQESTNNDEDSTS
Physicochemical Analysis
4594.56 Da
4.05
-9.13
-9.40
-0.2124
-1.46
0.48
-0.32
26.23
52.33
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2336.58
-37.80
78.0
76.0
161.0
321.0
1.0
48.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0037272 VERIFIED: NO
Provenance & Taxonomy
Rattus norvegicus [Animal]
10116
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide
RECORD: Rec_0129791 VERIFIED: YES
Provenance & Taxonomy
Rattus norvegicus [Animal]
Opioid
10116
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Opioid Analgesic Neuromodulator
PMID19164277 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19164277/
RECORD: Rec_0307186 VERIFIED: YES
Provenance & Taxonomy
Rattus norvegicus [Animal]
PENK(143-185)
10116
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Analgesic Pronociceptive Neuropeptide Neuromodulator Growth regulation Development regulation Receptor modulation
Mammalian: 1.1 hour; Yeast: 3 min; E. coli: >10 hour
PaperSource-linked PubMed record(s) for PENK(143-185) (Rattus norvegicus): PMID 19164277 PMID19164277 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19164277/
RECORD: Rec_0335057 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide
Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/