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MYP_019064
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Basic Information
Halibut Hb18
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
26 amino acids
C132H210N46O32S
Standard
Sequence
GFLGILFHGVHHGRKKALHMNSERRS
Physicochemical Analysis
2985.43 Da
11.72
4.11
3.70
0.1581
-0.57
0.43
-0.11
52.12
75.00
0.0769
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1264.13
-12.22
46.0
41.0
102.0
211.0
6.0
26.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0149633 VERIFIED: YES
Provenance & Taxonomy
Halibut [Animal]
Pleurocidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Aeromonas salmonicida 97-4
64 μg/mL
MIC
PMID12878506 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12878506/
RECORD: Rec_0157112 VERIFIED: YES
Provenance & Taxonomy
Hippoglossus hippoglossus [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
PaperNovel antimicrobial peptides derived from flatfish genes. Antimicrob Agents Chemother. 2003 Aug;47(8):2464-70. doi: 10.1128/AAC.47.8.2464-2470.2003. PMID: 12878506. PMID12878506 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12878506/
RECORD: Rec_0168348 VERIFIED: YES
Provenance & Taxonomy
Halibut [Animal]
Pleurocidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa Z61
64 μg/mL
MIC
PMID12878506 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12878506/
RECORD: Rec_0169765 VERIFIED: YES
Provenance & Taxonomy
Hippoglossus hippoglossus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
C-albicans C627
>64 μM
MIC
PaperNovel antimicrobial peptides derived from flatfish genes. PMID12878506 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12878506/
RECORD: Rec_0178500 VERIFIED: YES
Provenance & Taxonomy
Hippoglossus hippoglossus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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