Peptide Database

Peptide NameSLAY-screened peptide P4197

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC103H158N28O27S

DescriptionStandard

        VHGPPSRPAHVLMTLYYLSN
    

Molecular Weight2252.59 Da

Isoelectric Point (pI)8.58

Net Charge (pH 7.0)0.91

Net Charge (pH 7.4) 0.59

Charge Density (pH 7.0) 0.0453

GRAVY Index-0.05

Hydrophobic Moment 0.40

Boman Index0.17

Instability Index52.95

Aliphatic Index 92.50

Aromaticity 0.1000

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 853.35

LogP -6.68

H-bond Donors 29.0

H-bond Acceptors 31.0

Rotatable Bonds 64.0

Heavy Atoms 159.0

Ring Count 7.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0142532 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/