Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length506 amino acids

Chemical FormulaC2476H3952N642O724S15

DescriptionStandard

        YSRSPNEYEYWRTVKMFLCCWLALGALIPLTLATDPGVKVKLTAKGLEYGRQLGMAAIQKKLKTIRVPDISGKASVSPIGTVQYSLTNLQIVDVGLPTSTVALVPGTGVRLSISKAFIRLDGNWRVKYLRIIKDSGSFDLNVSDLTVGASIAIKSDETGRPTVNSVGCEATVGSASIHFHGGARLNWLYNLFKDFIDKAIRDALQNQICPLVTDAVSDLNPQLKTLNVLAKVDQYAEIEYSMVSSPAVTTSSIELGLKGEFYNIGKRQEPPFSAAAFDLPPQTDNMLYVGLSAFTANSAAFVYSTAGALSLYVTDDMVPRASPIRLNTRTFGAFIPQIAERFPGLMVKLLVKTSETPVVTFEPNNTTVQATGTVTAYAIQPNATLSPLFVLNLESSASARLFVNVMRVAGNVTLNKMDLTLGTSYVGEFKVTALNSVFQMVLKSVVVPQLNVQLAKGYPLPTIGKMTLVNTKLQVLKGYMLIGTDVQFNSTHGASQDSFLPWGTTL
    

Molecular Weight54778.71 Da

Isoelectric Point (pI)9.17

Net Charge (pH 7.0)9.00

Net Charge (pH 7.4) 8.48

Charge Density (pH 7.0) 0.0178

GRAVY Index0.16

Hydrophobic Moment 0.79

Boman Index0.15

Instability Index27.21

Aliphatic Index 100.36

Aromaticity 0.0850

Extinction Coeff. Reduced 52830.00

Extinction Coeff. Oxidized 53080.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0206800 VERIFIED: NO

Provenance & Taxonomy

OrganismGasterosteus aculeatus [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence