Peptide Database

Peptide NameInsulin glulisine

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Metabolic ▸ Glucose metabolism ▸ Antidiabetic

Metabolic ▸ Glucose metabolism ▸ Antidiabetic ▸ Hypoglycemic

Standard StatusStandard

Sequence Length51 amino acids

Chemical FormulaC258H388N64O77S6

DescriptionStandard

        GIVEQCCTSICSLYQLENYCNFVKQHLCGSHLVEALYLVCGERGFFYTPET
    

Molecular Weight5810.61 Da

Isoelectric Point (pI)4.98

Net Charge (pH 7.0)-3.12

Net Charge (pH 7.4) -3.52

Charge Density (pH 7.0) -0.0611

GRAVY Index0.22

Hydrophobic Moment 0.47

Boman Index0.18

Instability Index21.28

Aliphatic Index 85.88

Aromaticity 0.1373

Extinction Coeff. Reduced 5960.00

Extinction Coeff. Oxidized 6335.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2259.06

LogP -19.90

H-bond Donors 83.0

H-bond Acceptors 82.0

Rotatable Bonds 186.0

Heavy Atoms 405.0

Ring Count 10.0

Amide Bonds 55.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0339066 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]; Escherichia coli [Bacterium]

FamilyInsulin

Tax ID9606;562

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

DisulfideA6-A11, A7-B7, A20-B19

Other ModsAsnB3→Lys and LysB29→Glu substitutions

Bio-Activity Profile

Function

Antidiabetic Hypoglycemic Insulin analog

Half-LifeElimination half life= 42 min (SC injection)

PaperPubMed-linked source references: PMID:20429049; PMID:20424816; PMID:19496630; PMID:18076215; PMID:17764465; PMID:17703632; PMID:17316105; PMID:16706558; PMID:16193096 PMID20429049;20424816;19496630;18076215;17764465;17703632;17316105;16706558;16193096 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20429049/ PatentUS6960561