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MYP_018852
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Basic Information
Circulin-B
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Insecticidal/Pest control ▸ Insecticidal activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
31 amino acids
C141H232N38O41S6
Standard
Sequence
GVIPCGESCVFIPCISTLLGCSCKNKVCYRN
Physicochemical Analysis
3307.97 Da
8.33
1.70
1.40
0.0549
0.64
0.34
0.19
28.76
90.97
0.0645
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1257.31
-13.69
49.0
49.0
105.0
226.0
4.0
32.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0257491 VERIFIED: YES
Provenance & Taxonomy
Chassalia parviflora [Plant]
Cyclotide
Structure & Mods
cyclic peptide topology [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli
0.41 μM
MIC
PMID10430870 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10430870/
RECORD: Rec_0273447 VERIFIED: YES
Provenance & Taxonomy
Chassalia parviflora [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
5-19, 9-21, 14-27
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antiviral Antifungal
Virus:HIV:inhibition the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells
0.04-0.26 μM
EC50
PaperCyclotides as natural anti-HIV agents. Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. PMID: 18008336. PMID10430870;18008336;8920961 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10430870/
RECORD: Rec_0273949 VERIFIED: YES
Provenance & Taxonomy
Chassalia parvifolia [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
disulfide bond reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Hemolytic Cytotoxic Antiviral Insecticidal Anti-HIV Anti-Gram-positive
Staphylococcus aureus
13.5 μM
MIC
PaperPubMed PMID 4303114 | PubMed PMID 8920961 | PubMed PMID 10000000 | Tam JP et al. Proc. Natl. Acad. Sci. U.S.A. 1999; 96: 8913-8918 PMID4303114;8920961;10000000;10000 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/4303114/
RECORD: Rec_0308028 VERIFIED: YES
Provenance & Taxonomy
Chassalia parviflora [Plant]
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Bio-Activity Profile
Antimicrobial Antifungal Antiviral
Pseudomonas aeruginosa
25.5 μM
MIC
PaperChemical structure of circulin B.
RECORD: Rec_0311789 VERIFIED: YES
Provenance & Taxonomy
Chassalia parvifolia [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
disulfide bond reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Hemolytic Cytotoxic Antiviral Insecticidal Anti-HIV Anti-Gram-negative
Klebsiella oxytoca
8.2 μM
MIC
PaperPubMed PMID 4303114 | PubMed PMID 8920961 | PubMed PMID 10000000 | Tam JP et al. Proc. Natl. Acad. Sci. U.S.A. 1999; 96: 8913-8918 PMID4303114;8920961;10000000;10000 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/4303114/
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