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MYP_018852
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Basic Information
Circulin-B
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Insecticidal/Pest control ▸ Insecticidal activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
31 amino acids
C141H232N38O41S6
Standard
Sequence
GVIPCGESCVFIPCISTLLGCSCKNKVCYRN
Physicochemical Analysis
3307.97 Da
8.33
1.70
1.40
0.0549
0.64
0.34
0.19
28.76
90.97
0.0645
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1257.31
-13.69
49.0
49.0
105.0
226.0
4.0
32.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0000293 VERIFIED: YES
Provenance & Taxonomy
Chassalia parviflora [Plant]
cyclotide family
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
5-21; 9-23; 14-28
Bio-Activity Profile
Antimicrobial cyclotide family Antibacterial Host defense
PaperPDB 2ERI structural record; NMR; chain A; residues 5-31
RECORD: Rec_0004015 VERIFIED: YES
Provenance & Taxonomy
Chassalia parvifolia [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
disulfide bond reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Hemolytic Cytotoxic Antiviral Insecticidal Anti-HIV Anti-Gram-positive
Micrococcus luteus
500 μM
MIC
PaperPubMed PMID 4303114 | PubMed PMID 8920961 | PubMed PMID 10000000 | Tam JP et al. Proc. Natl. Acad. Sci. U.S.A. 1999; 96: 8913-8918 PMID4303114;8920961;10000000;10000 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/4303114/
RECORD: Rec_0010117 VERIFIED: YES
Provenance & Taxonomy
Chassalia parviflora [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
5-19, 9-21, 14-27
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antiviral Antifungal Hemolytic
blood type A human erythrocytes
550 μM
EC50
PaperCyclotides as natural anti-HIV agents. Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. PMID: 18008336. PMID10430870;18008336;8920961 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10430870/
RECORD: Rec_0013775 VERIFIED: YES
Provenance & Taxonomy
Chassalia parviflora [Plant]
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Bio-Activity Profile
Antimicrobial Antifungal Antiviral
Micrococcus luteus
>500 μM
MIC
PaperChemical structure of circulin B.
RECORD: Rec_0017959 VERIFIED: YES
Provenance & Taxonomy
Chassalia parviflora [Plant]
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Bio-Activity Profile
Antimicrobial Antifungal Antiviral
C. kefyr
29 μM
MIC
PaperChemical structure of circulin B.
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