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MYP_018824
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Basic Information
Unnamed
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ HMG-CoA Reductase Inhibitory
Metabolic ▸ Lipid metabolism ▸ Lipid-lowering activity
Standard
3 amino acids
C18H27N3O4
Standard
Sequence
IAF
Physicochemical Analysis
349.42 Da
5.53
-0.24
-0.44
-0.0800
3.03
0.09
1.06
6.67
163.33
0.3333
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
121.52
0.68
4.0
4.0
9.0
25.0
1.0
2.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0077379 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
Angiotensin-converting enzyme (ACE)
19.87
PaperLiang F., Shi Y., Shi J., Zhang T., Zhang R.. A novel angiotensin?I?converting enzyme (ACE) inhibitory peptide IAF (Ile?Ala?Phe) from pumpkin seed proteins: in silico screening, inhibitory activity, and molecular mechanisms. Eur. Food Res. Technol., 247, 2227-2237,.
RECORD: Rec_0315838 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hypolipidemic HMG-CoA Reductase Inhibitory
HMG-CoA reductase
PaperSilva M., Philadelpho B., Santos J., Souza V., Souza C., Santiago V., Silva J., Souza C., Azeredo F.; Castilho M., Cilli E., Ferreira E.. IAF, QGF, and QDF peptides exhibit cholesterol-lowering activity through a Statin-like HMG-CoA reductase regulation mechanism: in silico and in vitro approach. Int. J. Mol. Sci., 22, 11067, 2021.