Peptide Database

Peptide NameSLAY-screened peptide P3233

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC121H158N26O29S2

DescriptionStandard

        NPWWFLLQPMYDCTGFHVYS
    

Molecular Weight2504.84 Da

Isoelectric Point (pI)5.08

Net Charge (pH 7.0)-1.16

Net Charge (pH 7.4) -1.44

Charge Density (pH 7.0) -0.0582

GRAVY Index-0.07

Hydrophobic Moment 0.29

Boman Index0.31

Instability Index60.74

Aliphatic Index 53.50

Aromaticity 0.3000

Extinction Coeff. Reduced 13980.00

Extinction Coeff. Oxidized 13980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 863.30

LogP -2.53

H-bond Donors 30.0

H-bond Acceptors 31.0

Rotatable Bonds 69.0

Heavy Atoms 178.0

Ring Count 11.0

Amide Bonds 21.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0155775 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/