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MYP_018713
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Basic Information
DENV-2 gp (613-627)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Flavivirus ▸ Anti-Dengue virus
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
15 amino acids
C83H136N22O22S2
Standard
Sequence
CKIPFEIMDLEKRHV
Physicochemical Analysis
1858.23 Da
6.75
-0.16
-0.43
-0.0105
-0.23
0.43
-0.08
62.01
97.33
0.0667
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
716.45
-2.90
25.0
25.0
63.0
129.0
3.0
14.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0210345 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
DENV-2(dengue virus serotype 2):inhibition of virus entry in HUVECs(human umbilical vein endothelial cells)(70 ± 9% inhibition at 40 μM,44 ± 10% inhibition at 20 μM,40± 6% inhibition at 10 μM
19.08±2.52 μM
IC50
PMID29709564 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29709564/
RECORD: Rec_0264325 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-DENV Entry inhibition
DENV-2 (dengue virus serotype 2) | endothelial cells
19.08±2.52 μM
IC50
Mammalian: 1.2 h; Yeast: >20 h; E. coli: >10 h
PaperPeptides P4 and P7 derived from E protein inhibit entry of dengue virus serotype 2 via interacting with β3 integrin. | Cui X, Wu Y, Fan D, Gao N, Ming Y, Wang P, An J. | Antiviral Res. 2018 Jul;155:20-27. | DOI:10.1016/j.antiviral.2018.04.018 | PMID:29709564 PMID29709564 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29709564/
RECORD: Rec_0342546 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
DENV-1
PMID29709564 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29709564/
RECORD: Rec_0391091 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
DENV-2
40-50 % Inhibition
Inhibition
PMID29709564 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29709564/
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