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MYP_018675
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Basic Information
A3-APO
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
19 amino acids
C106H176N38O23
Standard
Sequence
RPDKPRPYLPRPRPPRPVR
Physicochemical Analysis
2350.77 Da
12.00
5.76
5.55
0.3031
-2.13
0.37
-0.75
62.29
35.79
0.0526
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
971.75
-7.99
33.0
29.0
64.0
167.0
9.0
18.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0124856 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Salmonella typhimurium
32 μM
MIC
PMID29051620 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29051620/
RECORD: Rec_0176167 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Dimer derivative [Synthetic]
PrAMP
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
It also prevents B. anthracis mortality by deactivating bacterial toxins (Otvos et al., 2014). Structure: It is of outstanding interest that A3-apo (residues 1-20) can bind in both the forward
Mouse 100 min
PaperThe designer proline-rich antibacterial peptide A3-APO is effective against systemic Escherichia coli infections in different mouse models
RECORD: Rec_0226493 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Klebsiella pneumoniae
4
MIC
PMID20031377 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20031377/
RECORD: Rec_0228566 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Vibrio vulnificus
64 μM
MIC
PMID29051620 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29051620/
RECORD: Rec_0246260 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
1-Amino cyclohexyl carboxylic acid
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Klebsiella pneumoniae ATCC 10031
4 μg/mL
MIC
PMID29309652 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29309652/
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