Peptide Database

Peptide Namea8 (IG-19 analogs)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length19 amino acids

Chemical FormulaC119H213N33O20

DescriptionStandard

        ILKLFKRIVKRILKFLRKL
    

Molecular Weight2426.17 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)7.76

Net Charge (pH 7.4) 7.54

Charge Density (pH 7.0) 0.4082

GRAVY Index0.49

Hydrophobic Moment 1.07

Boman Index-0.12

Instability Index42.43

Aliphatic Index 179.47

Aromaticity 0.1053

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 902.92

LogP 0.07

H-bond Donors 34.0

H-bond Acceptors 28.0

Rotatable Bonds 90.0

Heavy Atoms 172.0

Ring Count 2.0

Amide Bonds 18.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0414905 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetSalmonella typhimurium (KCTC 1926)

Activity8 μM

MethodMIC

PaperProkaryotic selectivity and LPS-neutralizing activity of short antimicrobial peptides designed from the human antimicrobial peptide LL-37. Peptides. 2012 Jun;35(2):239-247. doi: 10.1016/j.peptides.2012.04.004. PMID: 22521196. PMID22521196 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22521196/

RECORD: Rec_0425343 VERIFIED: YES