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MYP_018649
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Basic Information
FBP
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza A ▸ Anti-Influenza A virus
Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza B virus
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
16 amino acids
C87H139N35O18S
Standard
Sequence
RGAHIKGRWKSRCHRF
Physicochemical Analysis
1995.32 Da
12.00
5.92
5.60
0.3702
-1.44
0.40
-0.55
78.52
30.62
0.1250
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
892.84
-8.87
36.0
27.0
67.0
141.0
5.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0273415 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
SARS-CoV-2 (B.1.1.63, D614G):inhibition of infection in Vero-E6 cells
3 μg/mL
IC50
PMID35259078 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35259078/
RECORD: Rec_0281885 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-Influenza A virus Fusion inhibition
Influenza A virus (H1N1) | MDCK cells
1.955 μM
IC50
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperFusion-inhibition peptide broadly inhibits influenza virus and SARS-CoV-2, including Delta and Omicron variants. | Zhao H, Meng X, Peng Z, Lam H, Zhang C, Zhou X, Chan JF, Kao RYT, To KK, Yuen KY. | Emerg Microbes Infect. 2022 Dec;11(1):926-937. | DOI:10.1080/22221751.2022.2051753 | PMID:35259078 PMID35259078 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35259078/
RECORD: Rec_0299050 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-Influenza B virus Fusion inhibition
influenza B virus | MDCK cells
3.558 μM
IC50
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperFusion-inhibition peptide broadly inhibits influenza virus and SARS-CoV-2, including Delta and Omicron variants. | Zhao H, Meng X, Peng Z, Lam H, Zhang C, Zhou X, Chan JF, Kao RYT, To KK, Yuen KY. | Emerg Microbes Infect. 2022 Dec;11(1):926-937. | DOI:10.1080/22221751.2022.2051753 | PMID:35259078 PMID35259078 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35259078/
RECORD: Rec_0309150 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2 Hemolytic
PMID35259078 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35259078/
RECORD: Rec_0367593 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-SARS-CoV-2 Fusion inhibition
SARS-CoV-2 Delta | E6 cells
1.955 μM
IC50
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperFusion-inhibition peptide broadly inhibits influenza virus and SARS-CoV-2, including Delta and Omicron variants. | Zhao H, Meng X, Peng Z, Lam H, Zhang C, Zhou X, Chan JF, Kao RYT, To KK, Yuen KY. | Emerg Microbes Infect. 2022 Dec;11(1):926-937. | DOI:10.1080/22221751.2022.2051753 | PMID:35259078 PMID35259078 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35259078/
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