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MYP_018631
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Basic Information
Las[des1-10, Ala25]-NH2
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
17 amino acids
C80H150N24O18S2
Standard
Sequence
AKKKGKCKGPLKLVAKC
Physicochemical Analysis
1800.33 Da
10.16
6.77
6.54
0.3982
-0.55
0.47
-0.26
-15.56
74.71
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
702.27
-5.53
26.0
27.0
67.0
124.0
1.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0104097 VERIFIED: YES
Provenance & Taxonomy
Lasioglossum laticeps [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
7-17
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
100 μM
MIC
PMID22038181 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22038181/
RECORD: Rec_0119593 VERIFIED: YES
Provenance & Taxonomy
Lasioglossum laticeps [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
7-17
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Candida albicans
100 μM
MIC
PMID22038181 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22038181/
RECORD: Rec_0245501 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial
Human erythrocytes
200 μM
Hemolysis
PaperMonincová L, Slaninová J, Fučík V, et al. Lasiocepsin, a novel cyclic antimicrobial peptide from the venom of eusocial bee Lasioglossum laticeps (Hymenoptera: Halictidae). Amino Acids. 2012 Aug;43(2):751-761. doi:10.1007/s00726-011-1125-6. PMID22038181 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22038181/
RECORD: Rec_0327380 VERIFIED: YES
Provenance & Taxonomy
Lasioglossum laticeps [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
7-17
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa
100 μM
MIC
PMID22038181 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22038181/
RECORD: Rec_0369875 VERIFIED: YES
Provenance & Taxonomy
Lasioglossum laticeps [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
7-17
Bio-Activity Profile
Hemolytic
Hemolytic activity
200 μM
LC50
PMID22038181 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22038181/
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