Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length200 amino acids

Chemical FormulaC1014H1605N273O269S11

DescriptionStandard

        PKTMPMAHEPMLLLAVTEFIANSAAFTYFTAGALRRNISSDMLPRQFPLQLRTKSMEVFSPQLQERYPDQPMELHLWARRQPLLSCHPDALHGTLFSSAEAFVVLPNATRVPAFLLNIDANMTGKPTITRNRLGGTVKLTGLVPDPELALPAPWTTLPALCWAQTLPVPQVKRLETLLKFGLWLFGVPRANSKCCPRPVP
    

Molecular Weight22276.97 Da

Isoelectric Point (pI)9.64

Net Charge (pH 7.0)7.29

Net Charge (pH 7.4) 6.94

Charge Density (pH 7.0) 0.0364

GRAVY Index0.00

Hydrophobic Moment 0.55

Boman Index0.09

Instability Index58.92

Aliphatic Index 91.75

Aromaticity 0.0800

Extinction Coeff. Reduced 24980.00

Extinction Coeff. Oxidized 25230.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 8480.24

LogP -104.20

H-bond Donors 291.0

H-bond Acceptors 291.0

Rotatable Bonds 697.0

Heavy Atoms 1567.0

Ring Count 48.0

Amide Bonds 214.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0250804 VERIFIED: NO

Provenance & Taxonomy

OrganismAleadryas rufinucha [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria