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MYP_018590
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Basic Information
Antimicrobial peptide 5 (PGLa-like peptide) (XT-5)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
22 amino acids
C88H159N25O25S
Standard
Sequence
GMATKAGTALGKVAKAVIGAAL
Physicochemical Analysis
1999.42 Da
10.30
2.76
2.55
0.1253
0.92
0.58
0.36
-0.28
111.36
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
792.94
-8.40
28.0
29.0
68.0
139.0
0.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0054401 VERIFIED: YES
Provenance & Taxonomy
Silurana epitropicalis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Escherichia coli
80 μM
MIC
PaperHost-defense peptides in skin secretions of the tetraploid frog Silurana epitropicalis with potent activity against methicillin-resistant Staphylococcus aureus (MRSA)
RECORD: Rec_0064324 VERIFIED: YES
Provenance & Taxonomy
Xenopus tropicalis [Animal]
8364
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Candida albicans
100 μM
MIC
PaperPubMed PMID: 11738090 PMID11738090 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11738090/
RECORD: Rec_0071926 VERIFIED: YES
Provenance & Taxonomy
Xenopus tropicalis [Animal]
Antimicrobial peptide
8364
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Anti-Gram-negative
Mammalian: 30 hour; Yeast: >20 hour; E. coli: >10 hour
PMID11738090 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11738090/
RECORD: Rec_0111387 VERIFIED: YES
Provenance & Taxonomy
Silurana paratropicalis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Klebsiella pneumoniae
50 μM
MIC
PMID21498136 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21498136/
RECORD: Rec_0146550 VERIFIED: YES
Provenance & Taxonomy
Silurana epitropicalis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Toxicity
Less hemo.lytic
>160 μM
HC50
PaperHost-defense peptides in skin secretions of the tetraploid frog Silurana epitropicalis with potent activity against methicillin-resistant Staphylococcus aureus (MRSA)
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