Peptide Database

Peptide NameCorticotropin

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide precursor

Standard StatusStandard

Sequence Length39 amino acids

Chemical FormulaC208H317N55O61S

DescriptionStandard

        SYSMEHFRWGKPVGKKRRPIKVFPTDAEEESSESFPIEL
    

Molecular Weight4596.14 Da

Isoelectric Point (pI)6.52

Net Charge (pH 7.0)-0.44

Net Charge (pH 7.4) -0.72

Charge Density (pH 7.0) -0.0113

GRAVY Index-0.96

Hydrophobic Moment 0.59

Boman Index-0.18

Instability Index94.90

Aliphatic Index 47.44

Aromaticity 0.1282

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1870.92

LogP -15.99

H-bond Donors 65.0

H-bond Acceptors 63.0

Rotatable Bonds 150.0

Heavy Atoms 325.0

Ring Count 11.0

Amide Bonds 38.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0068279 VERIFIED: NO

Provenance & Taxonomy

OrganismLithobates catesbeiana [Animal]

FamilyPOMC

Tax ID8400

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsVal13 Amidation

Bio-Activity Profile

Function

Hormone precursor Neuropeptide precursor

RECORD: Rec_0108312 VERIFIED: YES

Provenance & Taxonomy

OrganismAquarana catesbeiana [Animal]

FamilyCorticotropin

Tax ID8400

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other Mods13:Valine amide

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator

Half-LifeMammalian: 1.9 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0158484 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/