Peptide Database

Peptide NameIslet amyloid polypeptide

Function Ontology

Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier

Delivery / Targeting ▸ Drug delivery vehicle

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic

Neurological / Signaling ▸ Pain modulation ▸ Pronociceptive activity

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Biological regulation

Regulatory peptide ▸ Cell-cell communication

Standard StatusStandard

Sequence Length37 amino acids

Chemical FormulaC167H273N51O54S2

DescriptionStandard

        KCNTATCATQRLANFLVRSSNNLGPVLPPTNVGSNTY
    

Molecular Weight3923.39 Da

Isoelectric Point (pI)9.50

Net Charge (pH 7.0)2.74

Net Charge (pH 7.4) 2.50

Charge Density (pH 7.0) 0.0740

GRAVY Index-0.25

Hydrophobic Moment 0.67

Boman Index-0.01

Instability Index25.38

Aliphatic Index 73.78

Aromaticity 0.0541

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1615.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1718.07

LogP -25.05

H-bond Donors 60.0

H-bond Acceptors 59.0

Rotatable Bonds 122.0

Heavy Atoms 274.0

Ring Count 5.0

Amide Bonds 43.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0432303 VERIFIED: YES

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyIslet amyloid polypeptide

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Disulfide2-7

Other ModsC-terminal amidation; Cys2-Cys7 disulfide

Bio-Activity Profile

Function

Amyloid formation inhibitor Protein aggregation inhibitor Hormone

Targethuman islet amyloid polypeptide (IAPP)

MethodThioflavin-T amyloid formation inhibition assay; TEM/CD confirmation

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