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MYP_018555
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Basic Information
Islet amyloid polypeptide
Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier
Delivery / Targeting ▸ Drug delivery vehicle
Hormonal / Endocrine ▸ Hormone peptide
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic
Neurological / Signaling ▸ Pain modulation ▸ Pronociceptive activity
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Standard
37 amino acids
C167H273N51O54S2
Standard
Sequence
KCNTATCATQRLANFLVRSSNNLGPVLPPTNVGSNTY
Physicochemical Analysis
3923.39 Da
9.50
2.74
2.50
0.0740
-0.25
0.67
-0.01
25.38
73.78
0.0541
1490.00
1615.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1718.07
-25.05
60.0
59.0
122.0
274.0
5.0
43.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0028940 VERIFIED: YES
Provenance & Taxonomy
Mus musculus [Animal]
Calcitonin
10090
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Amidation
2-7
Bio-Activity Profile
Hormone Calcium-regulatory peptide
PMID2679555 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2679555/
RECORD: Rec_0094001 VERIFIED: YES
Provenance & Taxonomy
Mus musculus [Animal]
Islet amyloid polypeptide
10090
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
Amidation
2-7
Bio-Activity Profile
Analgesic Pronociceptive Hormone Endocrine Metabolic regulation Physiological regulation Growth regulation Development regulation Receptor modulation
Mammalian: 1.3 hour; Yeast: 3 min; E. coli: 2 min
PaperSource-linked PubMed record(s) for Islet amyloid polypeptide (Mus musculus): PMID 2668946 PMID2668946 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2668946/
RECORD: Rec_0097590 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Cell-Cell Communication Drug Delivery Vehicle Blood-Brain Barrier
PaperNeuroPedia: neuropeptide database and spectral library PMID21821666 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21821666/
RECORD: Rec_0201209 VERIFIED: NO
Provenance & Taxonomy
Rattus norvegicus [Animal]; Mus musculus [Animal]
10116, 10090
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Amidation
2-7
Bio-Activity Profile
Hormone
RECORD: Rec_0211364 VERIFIED: YES
Provenance & Taxonomy
Rattus norvegicus [Animal]
Islet amyloid polypeptide
10116
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
Amidation
2-7
Bio-Activity Profile
Analgesic Pronociceptive Hormone Endocrine Metabolic regulation Physiological regulation Growth regulation Development regulation Receptor modulation
Mammalian: 1.3 hour; Yeast: 3 min; E. coli: 2 min
PaperSource-linked PubMed record(s) for Islet amyloid polypeptide (Rattus norvegicus): PMID 2357234 PMID2357234 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2357234/
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