Peptide Database

Peptide NameSLAY-screened peptide P1479

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC91H138N28O28S2

DescriptionStandard

        NGLDPCYNNCINYLNHIR
    

Molecular Weight2136.37 Da

Isoelectric Point (pI)6.72

Net Charge (pH 7.0)-0.17

Net Charge (pH 7.4) -0.46

Charge Density (pH 7.0) -0.0096

GRAVY Index-0.65

Hydrophobic Moment 0.48

Boman Index-0.06

Instability Index19.72

Aliphatic Index 86.67

Aromaticity 0.1111

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3105.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 933.02

LogP -10.20

H-bond Donors 32.0

H-bond Acceptors 31.0

Rotatable Bonds 66.0

Heavy Atoms 149.0

Ring Count 4.0

Amide Bonds 22.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0086262 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/