Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length192 amino acids

Chemical FormulaC954H1507N265O256S7

DescriptionStandard

        PGTHRDMLLLAVTDFLTKSAAFTYFTAGALRRNISGDTLPRRFPLQLRTKSMGVFAPQLQERYPELPMELQLSARRQPLLSCHPQALHGALFGSAEAFVVLPDATRVPAFLLDIDVNVTGKPSIRGNRLGGTVKLTGRVSSSGMHPGAPHPNSPPLAIWSFLSPPKVKRLETLLKFGLWLFGVPWANSECCP
    

Molecular Weight21009.25 Da

Isoelectric Point (pI)10.11

Net Charge (pH 7.0)9.38

Net Charge (pH 7.4) 9.00

Charge Density (pH 7.0) 0.0488

GRAVY Index-0.02

Hydrophobic Moment 0.57

Boman Index0.08

Instability Index57.01

Aliphatic Index 89.95

Aromaticity 0.0833

Extinction Coeff. Reduced 19480.00

Extinction Coeff. Oxidized 19605.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 8167.96

LogP -98.43

H-bond Donors 285.0

H-bond Acceptors 277.0

Rotatable Bonds 664.0

Heavy Atoms 1482.0

Ring Count 44.0

Amide Bonds 202.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0261158 VERIFIED: NO

Provenance & Taxonomy

OrganismCalypte anna [Animal]

FamilyBPI/LBP

Tax ID9244

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria