Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length507 amino acids

Chemical FormulaC2568H3990N634O745S16

DescriptionStandard

        MRTKAVPVLWGCFLLWSLYISSSQTMYPGIKARVTQRALDYAVQAGLEMIEDMIKEKKLPDLNGSESLEFLKIDYVDYNFSNIKINAFSFPNTSLAFVPGVGIKVLTNHGTTNISTNWAVKSPLFQDSGGADLFLSEIYFTGIIILTQNEFGHPVLKLQDCYAQASHAHVSFSGELSVLYNSFAEPMEKPILKNLNGMLCPIITNEVEALNVNLSTLEVITKVDNYTLVDFSLVGPPEITEHDLDLNLKGVFYPLENLVDPPFPPVPFELPDRGDSMIYIGVSEYFFKSASFAHFTAGAFGVTLSTKEISKHFIQNSQGLGNVLSQIAEIYILSQPFMLQIMATEPPTVSLQPGNFTLDIPASIMMLTQPENSTLQSIVSMDFVASTSVGLAILGQRLICSLSLKRFRLSLPESSRKDIKVVRFENILSSILHFGVLPLANARLQQGFPLPNPHKLSFVNSDIEVLEGFLLISTDLKYESPSKQQPSFHGWEDLSLLNGQWTGKATP
    

Molecular Weight56177.99 Da

Isoelectric Point (pI)5.14

Net Charge (pH 7.0)-14.60

Net Charge (pH 7.4) -15.50

Charge Density (pH 7.0) -0.0288

GRAVY Index0.11

Hydrophobic Moment 0.69

Boman Index0.17

Instability Index36.26

Aliphatic Index 100.93

Aromaticity 0.1006

Extinction Coeff. Reduced 48360.00

Extinction Coeff. Oxidized 48610.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0144834 VERIFIED: NO

Provenance & Taxonomy

OrganismIctidomys tridecemlineatus [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence