Peptide Database

Peptide NameSLAY-screened peptide P5334

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length10 amino acids

Chemical FormulaC47H70N10O13S

DescriptionStandard

        PPTCAPGYLP
    

Molecular Weight1015.18 Da

Isoelectric Point (pI)5.91

Net Charge (pH 7.0)-0.05

Net Charge (pH 7.4) -0.13

Charge Density (pH 7.0) -0.0052

GRAVY Index-0.07

Hydrophobic Moment 0.12

Boman Index0.31

Instability Index58.29

Aliphatic Index 49.00

Aromaticity 0.1000

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 325.32

LogP -2.34

H-bond Donors 11.0

H-bond Acceptors 14.0

Rotatable Bonds 22.0

Heavy Atoms 71.0

Ring Count 5.0

Amide Bonds 9.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0303072 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Familyp53-derived

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/