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MYP_018233
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Basic Information
Temporin-1BYa (Frogs, amphibians, animals)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
13 amino acids
C69H118N14O15
Standard
Sequence
FLPIIAKVLSGLL
Physicochemical Analysis
1383.76 Da
8.75
0.76
0.55
0.0584
2.02
0.47
0.68
17.52
210.00
0.0769
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
449.98
0.67
15.0
16.0
44.0
98.0
2.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0277444 VERIFIED: YES
Provenance & Taxonomy
Rana boylii [Animal]
Temporin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Staphylococcus aureus
15 μM
MIC
PaperIsolation of peptides of the brevinin-1 family with potent candidacidal activity from the skin secretions of the frog Rana boylii
RECORD: Rec_0283555 VERIFIED: YES
Provenance & Taxonomy
Rana boylii [Animal]
Temporin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Escherichia coli
>50 μM
MIC
PaperIsolation of peptides of the brevinin-1 family with potent candidacidal activity from the skin secretions of the frog Rana boylii
RECORD: Rec_0315532 VERIFIED: YES
Provenance & Taxonomy
Rana boylii [Animal]
Temporin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Candida albicans
>50 μM
MIC
PaperIsolation of peptides of the brevinin-1 family with potent candidacidal activity from the skin secretions of the frog Rana boylii
RECORD: Rec_0322004 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Temporin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0338444 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 38.5%, E 0.0%, T 23.1%, C 38.5% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
PaperYADAMP: yet another database of antimicrobial peptides PMID22325123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22325123/
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