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MYP_018223
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Basic Information
Pseudin-1 (Pseudin 1; Frogs, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
24 amino acids
C123H204N36O33
Standard
Sequence
GLNTLKKVFQGLHEAIKLINNHVQ
Physicochemical Analysis
2715.16 Da
9.70
1.93
1.62
0.0806
-0.14
0.69
0.07
-8.10
125.83
0.0417
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1141.02
-9.62
37.0
37.0
95.0
192.0
3.0
28.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0164312 VERIFIED: YES
Provenance & Taxonomy
Pseudis paradoxa [Animal]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Candida albicans
PaperPubMed PMID: 11689009 PMID11689009 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11689009/
RECORD: Rec_0167425 VERIFIED: YES
Provenance & Taxonomy
Pseudis paradoxa [Animal]
Pseudin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Escherichia coli
PMID11689009 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11689009/
RECORD: Rec_0197346 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Pseudin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Multifunction
CEM-SS
35.7 μM
IC50
PaperIdentification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database. PMID20086159 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20086159/
RECORD: Rec_0252549 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0271167 VERIFIED: YES
Provenance & Taxonomy
Pseudis paradoxa [Animal]
Pseudin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
4.5 μM
MIC
PaperL. Olson et al. / BBRC 288 (2001) 1001-1005. Pseudin-2: an antimicrobial peptide with low hemolytic activity from the skin of the paradoxical frog Evidence URLhttps://www.uniprot.org/uniprotkb/P83188/entry
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