Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length86 amino acids

Chemical FormulaC439H701N127O114S7

DescriptionStandard

        MFQCVAFISGRQLGMQALQAELKKINIPELSGKSGRVRYRFSGIHIRTFNIAQSTMAFSPGTGMKLSLDNVFIAVRGNWRMKYRFM
    

Molecular Weight9806.50 Da

Isoelectric Point (pI)11.30

Net Charge (pH 7.0)9.58

Net Charge (pH 7.4) 9.28

Charge Density (pH 7.0) 0.1114

GRAVY Index-0.03

Hydrophobic Moment 0.54

Boman Index0.03

Instability Index29.92

Aliphatic Index 79.42

Aromaticity 0.1163

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8480.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3931.48

LogP -36.38

H-bond Donors 141.0

H-bond Acceptors 132.0

Rotatable Bonds 333.0

Heavy Atoms 687.0

Ring Count 14.0

Amide Bonds 94.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0387880 VERIFIED: NO

Provenance & Taxonomy

OrganismCallorhinchus milii [Animal]

FamilyBPI

Tax ID7868

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence