Peptide Database

Peptide NameS-6K-F17-3GN (Derived from S-6K-F17)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length17 amino acids

Chemical FormulaC87H137N25O19

DescriptionStandard

        KKKKKKNGFAAWGAFGA
    

Molecular Weight1837.17 Da

Isoelectric Point (pI)10.70

Net Charge (pH 7.0)5.75

Net Charge (pH 7.4) 5.54

Charge Density (pH 7.0) 0.3385

GRAVY Index-0.95

Hydrophobic Moment 0.26

Boman Index-0.16

Instability Index-15.52

Aliphatic Index 23.53

Aromaticity 0.1765

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 743.92

LogP -6.01

H-bond Donors 26.0

H-bond Acceptors 25.0

Rotatable Bonds 65.0

Heavy Atoms 131.0

Ring Count 4.0

Amide Bonds 17.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0419655 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Confighydrocarbon-stapled side-chain cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Other ModsThe Ⓧ (position: 10 and 14) in sequence indicates 2-(4'-pentenyl) alanine. Ⓧ (10) and Ⓧ (14) are cross-linked by hydrocarbon stapling

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetEscherichia coli

Activity4.2 μM

MethodMIC

PaperTracy A Stone, Gregory B Cole, Huong Q Nguyen, Simon Sharpe, Charles M Deber. Influence of hydrocarbon-stapling on membrane interactions of synthetic antimicrobial peptides. Bioorg Med Chem. 2018 Mar 15;26(6):1189-1196. Epub 2017 Oct 21. PMID29275987 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29275987/

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